Doctor's Office
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Dr. Isaeff

Primary Care That Makes You Primary

Mark A. Isaeff, MD

Internal Medicine
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4.9/5 16 reviews

Get Started Today

This physician wants to get to know you and your health needs before you join their practice. Fill out the form to receive more information, or schedule a meeting with Dr. Isaeff.

MDVIP Annual Membership Fee

MDVIP’s annual fee covers the Wellness Program and generally can be made in quarterly, semi-annual and annual payments.

Quarterly
$450.00 every 3 months*

Semi-Annual
$900.00 every 6 months*

Annual
$1,800.00 each year*

I want to...

*MDVIP respects your privacy and will only use your personal information as stated in our Privacy Policy and Terms of Use. By providing your number, you are giving your express written consent to MDVIP to receive telemarketing calls or text messages using an automatic phone dialing system or an artificial or prerecorded voice at any number you may provide to MDVIP. You acknowledge that your consent to receive these communications is not required and that you may call the number listed above to get more information or enroll. You can contact MDVIP any time if you wish to stop receiving such messages by replying "STOP" via text or calling 1-877-764-2340. Text "HELP" for help. Message frequency may vary. Message/data rates may apply.

Residency

University of Texas Health Sciences Center at San Antonio
San Antonio, TX
Internal Medicine 1999-2001
Chief Resident, Internal Medicine 2001-2002
Excellence in Internal Medicine
Excellence in Outpatient Care

Internship

University of Texas Health Sciences Center at San Antonio
San Antonio, TX
Internal Medicine 1998-1999

Medical School

George Washington School of Medicine
Washington, DC
Doctorate of Medicine with Distinction 1998
Oscar Benwood Hunter Award
DF Kane, AF King, SM Dodek Award
Huron W. Larson Award
Pathology Honor Society Award

Undergraduate

University of California at Berkeley
Berkeley, CA
Bachelor of Science, Molecular Cell Biology 1992

American Board of Internal Medicine

Metropolitan Methodist

Texas

GOD, family and community

MDVIP Annual Membership Fee

MDVIP’s annual fee covers the Wellness Program and generally can be made in quarterly, semi-annual and annual payments.

Quarterly
$450.00 every 3 months*

Semi-Annual
$900.00 every 6 months*

Annual
$1,800.00 each year*

Doctor's Office
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Dr. Isaeff

Meet Mark A. Isaeff, MD


I believe that we all have different gifts and talents. For me, I have been given the gift of teaching and healing. I have an innate sense for identifying problems and illness in people and communicating them in understandable ways. Looking each person in the eye I give you my undivided attention. You are exceedingly valuable and infinite in worth. I will not judge you. As your doctor, I am your friend. And as your friend, I will share my gifts with you. In the end healing is easier when relationships are found.

Get Started Today

This physician wants to get to know you and your health needs before you join their practice. Fill out the form to receive more information, or schedule a meeting with Dr. Isaeff.

MDVIP Annual Membership Fee

MDVIP’s annual fee covers the Wellness Program and generally can be made in quarterly, semi-annual and annual payments.

Quarterly
$450.00 every 3 months*

Semi-Annual
$900.00 every 6 months*

Annual
$1,800.00 each year*

I want to...

*MDVIP respects your privacy and will only use your personal information as stated in our Privacy Policy and Terms of Use. By providing your number, you are giving your express written consent to MDVIP to receive telemarketing calls or text messages using an automatic phone dialing system or an artificial or prerecorded voice at any number you may provide to MDVIP. You acknowledge that your consent to receive these communications is not required and that you may call the number listed above to get more information or enroll. You can contact MDVIP any time if you wish to stop receiving such messages by replying "STOP" via text or calling 1-877-764-2340. Text "HELP" for help. Message frequency may vary. Message/data rates may apply.

Primary Care That Makes You Primary

A new healthcare model to suit your lifestyle
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Woman at Cafe

Benefits of joining Dr. Isaeff's practice with MDVIP

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MDVIP Wellness Program

Expect comprehensive screenings and tests and a custom wellness plan designed for you.

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Better Doctor-Patient Relationship

97% of MDVIP members are satisfied with their relationship (vs 58% in traditional PCP).

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Same/Next-Day Appointments

See Dr. Isaeff quickly and take your time during each appointment.

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Reachable 24/7

Reach Dr. Isaeff by phone after-hours and on weekends.

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Smaller Practice Size

MDVIP practices are smaller than most primary care practices, which means your doctor has more time to help you.

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Your Dedicated Doctor

See Dr. Isaeff when you go to the office — not someone else like a nurse practitioner or physician assistant

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Travel Benefits

If you need urgent care while traveling, your physician can help arrange your care with a local hospital, pharmacy or doctor.

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Medical Centers of Excellence

For patients who need care beyond what is available locally, MDVIP can connect your doctor with specialists at some of the country’s leading medical institutions

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Better Health Outcomes

Members have better control of chronic conditions like type 2 diabetes, high cholesterol and hypertension.

Frequently Asked Questions

Doctors who operate in the MDVIP models typically see far fewer patients than traditional primary care doctors. That gives them more time to develop deeper doctor-patient relationships that can lead to better outcomes. They can also offer conveniences that most primary care doctors can’t, including same- and next-day appointments. They’re available after hours for urgent matters. And they have time to focus on prevention. That focus begins with the MDVIP Wellness Program, which patients pay for with their annual membership fee.

Most MDVIP-affiliated primary care practices accept insurance (your physician can tell you whether they accept your specific insurance plan). Your annual fee pays for preventive care medical services that insurance usually doesn’t cover (e.g., advanced diagnostic testing and screenings). Your MDVIP-affiliated physician will continue to bill your insurance and charge copays, co-insurances and deductibles as he or she currently does for other medical services like sick visits.

MDVIP makes wellness and prevention easier by providing your physician with innovative tools and technology. MDVIP supports your physician’s practice and seeks to eliminate barriers to a positive healthcare experience. Your doctor will determine whether and how to incorporate these tools at his/her discretion.

MDVIP Annual Membership Fee

MDVIP’s annual fee covers the Wellness Program and generally can be made in quarterly, semi-annual and annual payments.

Quarterly
$450.00 every 3 months*

Semi-Annual
$900.00 every 6 months*

Annual
$1,800.00 each year*

Get Started Today

This physician wants to get to know you and your health needs before you join their practice. Fill out the form to receive more information, or schedule a meeting with Dr. Isaeff.

MDVIP Annual Membership Fee

MDVIP’s annual fee covers the Wellness Program and generally can be made in quarterly, semi-annual and annual payments.

Quarterly
$450.00 every 3 months*

Semi-Annual
$900.00 every 6 months*

Annual
$1,800.00 each year*

I want to...

*MDVIP respects your privacy and will only use your personal information as stated in our Privacy Policy and Terms of Use. By providing your number, you are giving your express written consent to MDVIP to receive telemarketing calls or text messages using an automatic phone dialing system or an artificial or prerecorded voice at any number you may provide to MDVIP. You acknowledge that your consent to receive these communications is not required and that you may call the number listed above to get more information or enroll. You can contact MDVIP any time if you wish to stop receiving such messages by replying "STOP" via text or calling 1-877-764-2340. Text "HELP" for help. Message frequency may vary. Message/data rates may apply.

Reviews from around the web

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09/05/2025 Grace Land
Dr. Isaeff has treated my family for over 20 years. He is the best and I highly recommend him.
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03/15/2019 Pamela Varnon
I cannot tell you what a piece of mind it is to work with Dr. Isaeff and his team They are very knowledgeable and they help us with medications and I have an acute bronchial problems and they get right on it. I think that through M.D. VIP my has been has been lucky enough with Dr. Isaeff’s guidance not to be on insulin
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02/21/2023 Lydia Kreidel
The kindness, competency and concern I experience from everyone in this office(from the office staff to Dr. Isaeff) each time I’m there is exceptional! Dr. Isaeff explains everything in a way that is easily understood. He welcomes questions and does not rush me through anything. I am so thankful and blessed to have Dr. Isaeff as my primary care physician.
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02/18/2022 Russell Swize
Dr. Mark Isaeff is one of the best doctors I have ever had. He is knowledgeable, caring and honest. He always has the best health interest of patients at heart. He does what is best for each patient and not what a government entity says is the best way. This doctor is top notch and is just wonderful!
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02/15/2019 Gary Gosinski
Dr Isaeff diagnosed thyroid cancer early in it"s development and as a result my cancer was completely removed without the need for therapy.
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02/24/2019 Liz Garza Williams
Dr Isaeff,
What a wonderful doctor we have in San Antonio, his staff are extremely helpful and fun to visit with. Mark really listens to me and he has a gentle way of helping me understand how to take better care of myself. I would recommend him to friends and family.
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03/18/2022 Tee Oh
Absolutely the most conscientious and thorough medical professional I have ever experienced.
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01/23/2019 Bette Turner
Having blood tests and sharing information is important to me and there is time for this which I appreciate.
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02/27/2020 William Chandler
Dr. Isaeff is very knowledgeable and is constantly working to keep abreast of anything new in medicine. I'm very impressed with his knowledge and how he can apply different ideas to your situation. I have not had a bad experience of any kind since I started with him and his practice.
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03/17/2022 Victor Negron
Dr. Isaeff practices medicine in a way that encompasses your entire person. Before he was my physician, doctor visits consisted of paying a co-pay, waiting in a room full of other patients for an hour, then spending 15 mins with the doctor. That all changed with Dr. Isaeff. He is an EXCELLENT DOC!
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02/24/2025 Robert Engle
We have been patients of Dr. Isaeff for many years. Couldn't have wished for a better doctor to take of my wife and myself. Highly recommend him.
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06/26/2025 Charles Hargis
Amazing doctor. He is not captured by big pharma, or any part of the medical industrial complex. A God fearing man who is passionate about preventative medicine.
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03/16/2019 Susan Roberts
I can’t say enough good things to really convey my feelings for Dr. Isaeff and the care he has given me over the years. He lives his core values which can be felt in everything he does. He always explains things so that I can understand. I never feel rushed in and out like cattle but rather all the staff makes me feel special and unique, they know me and seem to really care. It seems like a lot of money but when you know you are making your health a priority and get this kind of care and attention, it’s worth every cent.
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02/20/2022 Jose Dodier
Dr Isaeff restored my faith in medical services. I avoided having a primary doctor for over 30 years. This doctor is extremely current on medical advise for improved health. I truly enjoy my visits to his office. His advise has improved my health, both physically and mentally. I am driven to improve my health. Dr Isaeff has referenced specialist to address my injuries from my long cowboying history. I now sleep much better without using medication. I sincerely appreciate his medical knowledge and his detailed explanations pertaining to my health.
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02/18/2022 Cathy Bollinger
Dr. Isaeff and his staff are amazing! I started going to him about 10 years ago. Immediately, I knew I had made the right decision. He explained why he became a MDVIP dr and actually listened to my medical issues. He was unlike other doctors I had been to. He didn’t want to just write prescriptions to mask my ailments, he tried to determine the base causes for issues I experienced. Then he educated me on best practices to help heal me and for preventing further disease/illness.

Dr. Isaeff has always treated me with utmost respect and care. He has spent a lot of time listening to my concerns and educating me on medical advice specific to my needs based on my bloodwork and medical history, such as nutrition and weight loss.

He obviously stays on top of the latest medical information by reading, studying medical journals, and attending workshops/conferences. He shares up to date information with me that he thinks might apply to me.

Any time he has sent me to a specialist for broken foot, colonoscopy, etc, it is obvious the other professionals hold him in professional esteem by the kind remarks they’ve made. (Each one he’s sent me to have also been top doctors in their field, as well.) His staff have arranged the referrals and set up timely appointments for me. He has followed up with those specialists and checked on me, sharing and interpreting results with me making sure I understand and feel satisfied.

The staff of Dr. Isaeff are also fantastic! The people who work for and with him are extremely professional, yet friendly and personable. Each one has always greeted me by name and gives me more respect and attention than I’ve ever received in a medical office. They, as well as the doctor himself, make me feel as if I am their only patient and their personal friend. I know they are very busy and yet they take time to make me feel special! I’m sure they do this with all of their patients, this is very rare!

I drive 150 miles one way to see Dr.Isaeff because I have moved and just will not even try to find a replacement dr. Any time I call or text the office or even the doctor personally, the response is practically immediate with an apology for not responding faster! This is so uncommon! I truly appreciate the care I get from Dr. Isaeff as well as his staff.

Testimonials from patients of Mark A. Isaeff, MD

My doctor is so intuitive!

from Elizabeth in TX • March 18, 2024
I feel very fortunate to have a doctor that takes the time to really study my blood work. He has help me so much. Im feeling better and doing great. Thank you Doctor Isaeff, Debbie, Shawn and Bobbie make such a great team. Thank you all so much for all your attention to my health. Love you guys, May God bless you and keep you!

Dr Mark Isaeff best doctor EVER!!

from Don in TX • March 12, 2024
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Dr Mark Isaeff is the most professional and knowledgeable doctor I have ever had and would never go anywhere else with to trust my health.

My Doctor My Friend

from Jonathan in TX • February 11, 2024
Dr. Mark Isaeff is not only my Doctor but also my friend! I have been with him for many years. I have often felt that Dr. Mark has helped to extend my life. I am 72 and feel like a young man . He has guided me thru many health issues and gotten me where I want to be. He is kind, professional and always caring . He listens to my medical issues and finds a solution to them promptly. He is available Read more...

Dr. Mark Isaeff

from William in TX • February 11, 2024
Mark is an outstanding Christian doctor who knows his business. He works hard to help me be as healthy as possible. He is a man of love and concern. 

Dear dr. Isaeff

from abel in TX • January 19, 2024
You have been my PCP for over 30 years and I will be 94 yrs old in 2024 and in pretty good shape as far as my health goes. Thank you very, very much for doing an outstanding job in getting me here. 

The Office of Mark A. Isaeff, MD


Locations & Hours

Primary Office

7955 Heuermann Road
San Antonio, TX 78256

call 210.572.4431

Get Directions

Hours

Mon 8:30 AM - 5:00 PM
Tue 8:30 AM - 5:00 PM
Wed 8:30 AM - 3:00 PM
Thu 8:30 AM - 5:00 PM
Fri 8:30 AM - 12:00 PM
Sat Closed
Sun Closed

MDVIP Annual Membership Fee

MDVIP’s annual fee covers the Wellness Program and generally can be made in quarterly, semi-annual, and annual payments.

Quarterly
$450.00 every 3 months*

Semi-Annual
$900.00 every 6 months*

Annual
$1,800.00 each year*

Get Started Today

This physician wants to get to know you and your health needs before you join their practice. Fill out the form to receive more information, or schedule a meeting with Dr. Isaeff.

MDVIP Annual Membership Fee

MDVIP’s annual fee covers the Wellness Program and generally can be made in quarterly, semi-annual and annual payments.

Quarterly
$450.00 every 3 months*

Semi-Annual
$900.00 every 6 months*

Annual
$1,800.00 each year*

I want to...

*MDVIP respects your privacy and will only use your personal information as stated in our Privacy Policy and Terms of Use. By providing your number, you are giving your express written consent to MDVIP to receive telemarketing calls or text messages using an automatic phone dialing system or an artificial or prerecorded voice at any number you may provide to MDVIP. You acknowledge that your consent to receive these communications is not required and that you may call the number listed above to get more information or enroll. You can contact MDVIP any time if you wish to stop receiving such messages by replying "STOP" via text or calling 1-877-764-2340. Text "HELP" for help. Message frequency may vary. Message/data rates may apply.

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