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Matthew M. O'Brien, MD

Family Medicine

Hospital Affiliations
Christiana Care Hospital System
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Dr. O'Brien

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MDVIP Annual Membership Fee
MDVIP’s annual fee covers the Wellness Program and generally can be made in quarterly, semi-annual and annual payments.
Quarterly
$550.00*
Semi-Annual
$1,100.00*
Annual
$2,200.00*
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About Matthew M. O'Brien, MD

I am a patient-focused primary care physician who believes in personalized care and that each patient is unique, not a number. My MDVIP-affiliated practice offers same- or next-day appointments, phone calls that are answered in person, and visits that are relaxed and not rushed. My patients can come in for an appointment or call me after hours (even when traveling) for more urgent matters.

My practice offers services, including comprehensive, advanced health screenings and diagnostic tests, that go far beyond those found in concierge medicine practices. The lab findings, tests and screening results from the annual MDVIP Wellness Program allow us to work together to create a more individualized wellness plan. I find that the enhanced doctor-patient relationship offered in my practice combined with the services included in the annual MDVIP Wellness Program are tools that, if properly followed, can potentially help extend the number of healthier or disease-free years of life.

I see patients from Wilmington, Delaware, as well as the Greenville, Hockessin, Centreville, Chadds Ford and Southern Chester County areas. I was born and raised in Wilmington. Both of my parents were physicians, as are two of my siblings. I am a graduate of Columbia University with a degree in applied physics engineering. I worked for a local chemical company before realizing that it was not my calling. I have been practicing with an individualized approach to medicine since I completed my medical degree at Jefferson Medical College and residency at Christiana Care more than 20 years ago.

I am a member of the American Academy of Family Physicians and the Delaware Academy of Medicine and an appointed clinical instructor for the ChristianaCare Family Medicine Residency Program, as well as for Jefferson Medical College. I am affiliated with the ChristianaCare system.

Residency

Christiana Care Hospital System
Wilmington, DE
Family and Community Medicine 1998-2000

Internship

Christiana Care Hospital System
Wilmington, DE
1997-1998

Medical School

Jefferson Medical College
Philadelphia, PA
Doctorate of Medicine 1997

Undergraduate

Columbia University, School of Engineering and Applied Science
New York, NY
Bachelor of Science, Applied Physics Engineering 1986

Christiana Care Hospital System

Preceptor, Medical Students and Residents 2003-present

American Academy of Family Physicians
American Medical Association
Medical Society of Delaware

Delaware

Benefits of joining Dr. O'Brien's practice with MDVIP

MDVIP Wellness Program
Expect comprehensive screenings and tests and a custom wellness plan designed for you.
Better Doctor-Patient Relationship
97% of MDVIP members are satisfied with their relationship (vs 58% in traditional PCP).
Same/Next-Day Appointments
See Dr. O'Brien quickly and take your time during each appointment.
Reachable 24/7
Reach Dr. O'Brien by phone after-hours and on weekends.
Smaller Practice Size
MDVIP practices are smaller than most primary care practices, which means your doctor has more time to help you.
Your Dedicated Doctor
See Dr. O'Brien when you go to the office — not someone else like a nurse practitioner or physician assistant
Travel Benefits
If you need urgent care while traveling, your physician can help arrange your care with a local hospital, pharmacy or doctor.
Medical Centers of Excellence
For patients who need care beyond what is available locally, MDVIP can connect your doctor with specialists at some of the country’s leading medical institutions
Better Health Outcomes
Members have better control of chronic conditions like type 2 diabetes, high cholesterol and hypertension.
O'Brien Sign
O'Brien Office

The office of Matthew M. O'Brien, MD

Primary Office
1401 Foulk Road Suite 202
Wilmington, DE 19803
Get Directions
Hours
Mon 9:00 AM - 4:30 PM
Tue 9:00 AM - 4:30 PM
Wed 9:00 AM - 4:30 PM
Thu 9:00 AM - 4:30 PM
Fri 9:00 AM - 4:30 PM
Sat Closed
Sun Closed

What our members are saying

Dr. O’Brian has been taking care of me for several years. I first met him when he was taking care of my Mother. When she had to go to a nursing home he was there for me. He helped me understand when she died. I asked for facts about her dying. He answered my questions honestly. He has always been honest with me. He has a good sense of humor as when I asked him about losing weight, his response…
Anthony
December 14, 2022
Last year I broke my leg and luckily, I did not require surgery . My 9 week stint on crutches was coming to an end and I was so pleased to be able to start walking. However , when I resumed walking with enthusiasm, I developed moderate to severe swelling and pain of my foot and calf below the fractured Tibia. Dr O'Brien arranged a visit and provided important reassurance that this was…
Katherine
March 22, 2020
Dr. O'Brian has been my doctor for a number of years prior to being with MDVIP. He and his staff have always tried to give the best of service. He has always had a warm word to greet you with. His humor and ability to connect takes the uneasiness levels way down. He is on top of his game and always follows up with me to confirm any questions. I have referred friends to him before and would always…
William
March 12, 2020
Image provided by: William
Dr. O’Brien is an excellent diagnostician. He is a doctor who intently listens to his patients then, thoughtfully asks questions. Often he’ll consult a web site that can help me but most often he quickly diagnoses the problem. He is never hesitant to consult another doctor if necessary, or order tests to aid in his diagnosis. He also recommends specialists who treat specific ailments or…
Ann
March 10, 2020
Image provided by: Ann

Reviews from the web

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10/21/2025 Drew Dalton
Very attentive and responsive doctor and staff.
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09/24/2025 Margaret
Dr. O’Brien is a dedicated and thoughtful practitioner. He has called me back directly just to answer my questions. He listens to his patients and wants to work with them to get the best possible care.
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04/22/2025 Ross W
Always a nice and relaxed visit
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04/21/2025 Todd Anderson
Dr. O’Brien is a very caring and knowledgeable doctor supported by an excellent staff. They all continue to provide me with an exceptional level of expertise and attention to my healthcare needs.
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04/17/2025 Julie McGinnis
Great medical practice. Responsive, attentive and informed. The office staff go above and beyond to help solve problems quickly.
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04/11/2025 Jessica
Dr. Obrien and his staff are amazing! I have been with them for many years and they have always gone above and beyond for me. When it comes to something as important as our health its nice knowing I have a doctor I trust. He is very down to earth and he has a great personality. I have been through tough times with different aspects of my health, but with his treatment and advice I am able to live a more normal life. I wouldn't want anyone else in charge of my care. They deserve 5 stars all day.
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04/09/2025 Mike Tate
He always sees me quickly and takes time to listen.
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04/03/2025 ahidell resume
Been a patient with Dr. O'Brien for years now and cannot think of anyone I trust with my care more as my PCP. He and his staff work with me care about my health and listen when I say I have an issue. Truly a wonderful doctor we are blessed to have in our area.
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03/31/2025 Emily Kook
Initially, I was a little hesitant to complete this survey for fear that my words would not do the practice justice. But after further thought, I decided to share my experience in the hopes that other people could benefit from the wonderful care of Dr. O’Brien and his staff at Brandywine Hundred Family Medicine. I am so grateful for the guidance, knowledge & advice that Dr O’Brien has provided me over the years. However, the bedside manner of the doctor nurses, & office staff is what sets them apart from other healthcare providers - they have an incredible gift of making patients feel comfortable & always a top priority. They have truly become family. Thank you so much for everything that you all do!
Emily
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03/26/2025 Bob Tattersall
GETTING APPOINTMENTS QUICKLY. SHORT WAITING TIME. QUALITY TIME WITH DR. O'BRIEN. EXCELLENT EXPLANATION OF TEST RESULTS.
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03/13/2025 Gerard Aulisa
Dr O’Brien treats his patients in a caring and informative manner. He takes his time and makes sure all of your questions are answered in an easy to understand way. He allows you to participate in your care and never talks down to you. The rest of the office staff are very kind and always try to make sure you’re happy with your experience. I highly recommend Dr O’Brien.
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12/23/2024 David Cress
Quick availability to see Dr O'Brien, when needed.
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12/22/2024 J Vincent
Dr. OBrien and team always answer the phone, schedule a visit or referral quickly when needed, and take the time to have a conversation and my health, questions, next steps.
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06/05/2024 Tom Frost
Dr Matt has helped me lose 60 lbs since Covid and I’ve kept it off!! I would highly recommend this practice if you want to feel like you have a health advocate on your side…Thanks Matt
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02/29/2024 Teddy Hughes
He is the man. He is very caring, has great communication, and a has great network in the healthcare industry. Anybody would be lucky to have him as a doctor. Thank you for all of the help the past 2 years!
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12/27/2023 Christopher Purfield
Dr. O'Brien gave me an incredible experience! Both he and the staff there are very polite and relatable. Dr. O'Brien was very direct with answering questions and is clearly a very knowledgeable doctor.
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12/26/2023 Marlene Marks
Dr. O'Brien is a caring and confident doctor who gives me as much time as I need to explain my conditions and concerns. He is very well educated and up to date on the latest medical advances.
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11/26/2023 Kimberly MacNeill
Dr O’Brien is one of the most caring and patient focused physicians I’ve known. His attention to detail and listening to my needs is rare in todays medical environment. I trust and value his insights and always know I will be well cared for. I wish more physicians would take the time to listen to their patients the way Dr. O’Brien does. He’s just a gem!
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11/13/2023 Rhonda L
Dr. O’Brien is caring, patient and a compassionate doctor. He takes his time to listen about my concerns and never rushes me. If I have any questions, he thoroughly explains the answer so that I understand. His office staff is very nice and goes out of their way to ensure I am taken care of. I use a wheelchair and Dr O’Brien has personally taken me back to the waiting room to wait for my husband. He is so kind!
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10/24/2023 Joan Henke
Dr. O’Brien is excellent! He is a Doctor that listens and cares! He is marvelous Very thorough and good !
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10/14/2023 Jennifer Haupt
I am extremely grateful for the exceptional care I have received from Dr. O'Brien. What sets him apart is his dedication to spending quality time with his patients. He listens and never rushes appointments. Dr. O'Brien also is very responsive after business hours so is always available no matter when and where I have been. Additionally, Dr. O'Brien cares about your well-being and doesn't rely solely on medications to address problems. I have had several challenges medically and I am so grateful that I have an incredible doctor I can count on. When Dr. O'Brien switched to MDVIP I was wondering what would change as a result of this and I am even happier then I was before. His office is supportive and the screenings added with MDVIP have provided me with great preventive support and has helped me live a healthier life. If you are looking for a fantastic primary physician with the best bedside manner, Dr. O'Brien is the doctor you want!
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09/18/2023 martha white
Dr. O'Brien has always made himself available when I have health issues that arise in between my "regular" appointments. He is patient with me as a patient too. He takes the time to explain what we can do to improve my situation.
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08/22/2023 Kelly Hughes
I have been a patient for 30 years ( or more) I first saw him as a resident. I love his sense of humor and his deep care! Dr. Matt is smart, caring, and truly cares. I trust him with my life, my mom, my son… I have sent many people to him because I believe he is worth it! Thank you for always being there. And btw his staff is great, I love them always helpful.
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10/26/2022 d clymer
Requires you pay 1,800 to be a patient. To bad doctor's who care don't exist anymore
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08/28/2022 Ernest F Ruppe
Excellent Visit
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08/08/2022 R Bowers
The staff is very professional and knowledgeable. I have no complaints and appreciate the service Dr. O’BRIEN and his staff provide.
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06/17/2022 Bartolo Puglisi
I have been a patient of Dr O'Brien for 10+ years. I have always found him deeply knowledgable about any issue I present. He is a strong listener and has always provided the time necessary to me to discuss and seek his counsel for my medical concerns. I would not hesitate to recommend Dr O'Brien to any member of my family and friends. I consider myself extremely fortunate to have him as a medical resource.
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01/19/2022 Rosalie CIlia
Dr. O'Brien always takes his time to listen and address my medical issues. Staff are always helpful and pleasant to deal with. Glad he is my physician.
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02/16/2020 Lew Ledyard
Dr. O’Brien is great. He always has time, patience and knowledge.
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02/06/2020 Ann Albosta
Dr. O’Brien is a caring, intelligent, experienced physician. He spends as much time as is needed with all patients. He explains what he thinks as well as how those conditions are applicable to your case. He has never been wrong with me or with my husband. I am quite pleased with Dr. O’Brien and his practice and I’m not sure I could easily change doctors to another within the practice.
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10/01/2019 Leah O'Brien
Attentive doctor that actually cares about how I’m doing. The doctor is always friendly. The medical assistants really know what they’re doing - the only people I trust to give me flu shots!
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05/06/2019 Margo Kwiatkowski
Sickens me to choose 1 star. After being a patient long before Dr.obrian even started there. I was forced out due to a complete change in service offered . Upon finding a new practice . Which I have my first appointment at tomorrow. The office staff refused to send over my medical records when requested. They claim there is a 25 dollar fee to send medical records which I was unaware of. Now I will not have what I need to move forward at a new practice. Beware, this practice will leave you stranded as far as your health goes. Then make it nearly impossible to see a new DR. Very pathetic.
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01/17/2019 Anthony Eros
After being required to find a new doctor because I was not willing to pay $1,800/year to join their new boutique practice, I was forced to pay $25 for the "privilege" of leaving the practice and ransoming my medical records. The office staff's attitude was "that's our policy, so live with it." Very short-sighted on the part of Dr. O'Brien. It's a pretty low-class way to treat your patients; but hey, it's all about the VIPs now, I suppose.

Frequently Asked Questions

Doctors who operate in the MDVIP models typically see far fewer patients than traditional primary care doctors. That gives them more time to develop deeper doctor-patient relationships that can lead to better outcomes. They can also offer conveniences that most primary care doctors can’t, including same- and next-day appointments. They’re available after hours for urgent matters. And they have time to focus on prevention. That focus begins with the MDVIP Wellness Program, which patients pay for with their annual membership fee.

Most MDVIP-affiliated primary care practices accept insurance (your physician can tell you whether they accept your specific insurance plan). Your annual fee pays for preventive care medical services that insurance usually doesn’t cover (e.g., advanced diagnostic testing and screenings). Your MDVIP-affiliated physician will continue to bill your insurance and charge copays, co-insurances and deductibles as he or she currently does for other medical services like sick visits.

MDVIP makes wellness and prevention easier by providing your physician with innovative tools and technology. MDVIP supports your physician’s practice and seeks to eliminate barriers to a positive healthcare experience. Your doctor will determine whether and how to incorporate these tools at his/her discretion.

**The message above is a personal introduction from the physician, intended to help you get to know them better. The views, opinions, and statements expressed above are solely those of the physician and do not necessarily reflect the views or positions of MDVIP. This content is intended for general background purposes only and does not constitute medical advice, diagnosis, or treatment. Any mentions of expertise or quality of care are personal expressions and should not be interpreted as guarantees of performance or outcomes.