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Karen-Gail Brandse, MD

Internal Medicine

Hospital Affiliations
Metro West Medical Center, Braintree Rehabilitation Hospital, Northeast Specialty Hospital
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Dr. Brandse

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This physician has limited availability and may have a Waiting List. Fill out the form to receive more information about Dr. Brandse.
MDVIP Annual Membership Fee
MDVIP’s annual fee covers the Wellness Program and generally can be made in quarterly, semi-annual and annual payments.
Quarterly
$600.00*
Semi-Annual
$1,200.00*
Annual
$2,400.00*

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About Karen-Gail Brandse, MD

As an MDVIP-affiliated primary care physician, my main objective is to help you achieve a healthy, rewarding lifestyle. I have a limited practice in order to completely focus on wellness, prevention and early detection. As your internist, I will partner with you on a personal level by caring, listening, educating and advocating for you. I can be your private physician, healthcare partner and coach, helping you improve the overall quality of your life. My goal is to assist you in reaching your goals and enjoying the healthy life you deserve.

I am one of the few female physicians in the MetroWest area of Massachusetts providing this type of personalized healthcare. Similar to concierge medicine practices, I also offer conveniences like same- or next-day appointments that start on time. My internal medicine practice is located adjacent to MetroWest Medical Center and serves the communities of Natick, Dover, Sherborn, Framingham, Wayland, Sudbury and beyond. I invite you to come to my office and feel welcomed by the relaxing atmosphere and individualized attention offered by me and my staff during your visits. I am affiliated with MetroWest Medical Center, Braintree Rehabilitation Hospital and Northeast Specialty Hospital.

Fellowship

Columbia Metro West Medical Center
Framingham, MA
Internal Medicine 1995-1998

Internship

Tygerberg Hospital
Parow, Republic of South Africa
1980-1981

Postgraduate

Tygerberg Hospital
Parow, Republic of South Africa
1980-1981

Undergraduate

University of Stellenbosch
Stellenbosch, Republic of South Africa
Doctorate of Medicine 1979

The American Board of Internal Medicine
Medical and Dental Council, South Africa 1981
General Medical and Dental Council, United Kingdom 1994

Metro West Medical Center
Braintree Rehabilitation Hospital
Northeast Specialty Hospital

Medical Director, Oak Knoll Healthcare and Rehabilitation Center, Framingham, MA 1998-2002

Metro West Medical Center
- Advisory Committee 1998-2001
- Search Committee for Surgery Chief 2004
- Board of Breast Health 2007-present

Benefits of joining Dr. Brandse's practice with MDVIP

MDVIP Wellness Program
Expect comprehensive screenings and tests and a custom wellness plan designed for you.
Better Doctor-Patient Relationship
97% of MDVIP members are satisfied with their relationship (vs 58% in traditional PCP).
Same/Next-Day Appointments
See Dr. Brandse quickly and take your time during each appointment.
Reachable 24/7
Reach Dr. Brandse by phone after-hours and on weekends.
Smaller Practice Size
MDVIP practices are smaller than most primary care practices, which means your doctor has more time to help you.
Your Dedicated Doctor
See Dr. Brandse when you go to the office — not someone else like a nurse practitioner or physician assistant
Travel Benefits
If you need urgent care while traveling, your physician can help arrange your care with a local hospital, pharmacy or doctor.
Medical Centers of Excellence
For patients who need care beyond what is available locally, MDVIP can connect your doctor with specialists at some of the country’s leading medical institutions
Better Health Outcomes
Members have better control of chronic conditions like type 2 diabetes, high cholesterol and hypertension.
Dr. Brandse Hallway
Dr. Brandse Reception
Dr. Brandse Waiting Room

The office of Karen-Gail Brandse, MD

Primary Office
67 Union Street Medical Office Building, Suite 104
Natick, MA 01760
Get Directions
Hours
Mon 8:30 AM - 4:00 PM
Tue 8:30 AM - 4:00 PM
Wed 8:30 AM - 4:00 PM
Thu 8:30 AM - 4:00 PM
Fri 8:30 AM - 12:00 PM
Sat Closed
Sun Closed
I like Dr. Brandse but first I have to start with her office - beautiful art work, photography, comfortable couches. I feel like I'm at a cafe overseas somewhere having a cigarette (I don't smoke), glass of wine (I don't drink) and reading a magazine (I do read). Dr. Brandse has always made me feel comfortable over the years first with our casual conversation (she laughs at my jokes) and with all…
Tom
March 20, 2024
THAT IS HOW I FEEL ABOUT DR. BRANDSE. SHE IS ALWAYS THERE FOR ME WHEN I NEED HER. IF I DON'T CALL HER WHEN I HAVE A PROBLEM SHE REPRIMANDS ME, LIKE A FRIEND WOULD. THAT IS EXACTLY WHAT HAPPENED. I WAS ON VACATION AND FORGOT MY MEDS. I CALLED DR. BRANDSE ON A SUNDAY MORNING. NO PROBLEM. SHE CALLED THE LOCAL PHARMACY AND MY MEDS WERE WAITING FOR ME I DID NOT HAVE TO TELL HER ALL THE…
RITA
March 11, 2024
I started taking an injection to help with my bone loss and was really concerned about the long- and short-term side effects. I made an appointment with my doctor to discuss my concerns. She shared a personal story with me which helped me decide that the benefits of the medication will outweigh the risks, especially when I get older. If I don't start the medication now and then start 10…
Elizabeth
February 13, 2024
Dr. Karen-Gail Brandse and staff never misses a return call! My husband and I couldn’t be happier with our care. We feel blessed to have Dr. Brandse and her staff overseeing our health.
Joanne
February 12, 2024

Reviews from the web

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03/30/2025 David Tesini
I am fortunate to be a patient in Dr brandse’ practice. Thanking the whole team for my wonderful care
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03/18/2025 Sherry Anne Bryant
My doctor is tops in my book! She is "tuned in" to my overall health, listens intently to my questions and concerns, responds with suggestions and advice. I value her opinion and trust her judgement.
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02/19/2025 Patti Bamberger
Dr Brandse is a lovely caring physician who I loved to see and chat with about the world and about my health. She has put me at ease many times and she understands my anxiety.
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08/27/2024 Frank Fitzgerald
Excellent doctor. She listens and made it a point to know me a bit instead of just looking at numbers on a chart. She is very responsive and thorough.
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03/15/2024 Andrea Walters
My doctor is so caring. She not only looks at a person as a patient, she views her patience as individuals and is interested in their lives, and their overall well-being. This includes not only their physical health, but also their mental health and safety. She It’s always available to speak to me and is very responsive to my needs. She is extremely kind. She has a lovely bedside manner. She is soft-spoken And she listens. I think she is a wonderful physician and a lovely human being. I cannot imagine having a better position. Her office staff is equally wonderful, helpful and understanding.
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02/17/2024 Linda Wise
Dr. Brandse Is a hands on doctor. She is very knowledgeable and easy to talk to. Very responsive when I need her.
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02/16/2024 Marilynn Raben
Dr. Brandse is smart, kind, thorough, responsive, and shares great resources. Her office staff is amazingly efficient. I am so pleased to be a patient of Dr. Brandse's.
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02/14/2024 Rita Hettinger
I HAVE COMPLETE CONFIDENCE IN DR. BRANDSE. WHEN I AM WITH HER (IN PERSON OR ON THE TELEPHONE) SHE IS AWARE OF ME, MY PHYSICAL CONDITION, AND TREATS ME WITH HER COMPLETE ATTENTION. IT AMAZES ME HOW MUCH SHE KNOWS ABOUT ME WHEN SHE IS NOT IN HER OFFICE. I FEEL LUCKY TO BE ONE OF HER PATIENTS.
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01/25/2024 Mary Connelly
I just left DrBrandse ‘s office and I have never felt more cared for .

DrBrandse is unequaled as a
physician , diagnostician and caring
practitioner. She and her staff are rockstars .

She listens , never rushes and is always available when needed .

On the rare occasions she has taken vacation even though she has phenomenal local coverage , she has still contacted me to check in .
I recently heard another physician at the hospital refer to her as the “most brilliant diagnostician “he had ever known .
What I value most of all though is her genuine effort and holistic approach at every visit to make sure my health and overall wellbeing is more than optimum.
I was blessed the day I found her . She truly changed my health and my life .
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03/16/2023 Cindy Mushnick
Dr Brandse is a great PCP. Very caring and very thorough. The staff is long term and fabulous. MDVIP is a very comprehensive program. The yearly physical is far superior to other health plans.
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02/09/2023 Carol
The care I receive from Dr Brandse is and has always been top notch. An asset to the medical field adn with MDVIP it is even better!!
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02/09/2023 Sara Dwyer
Dr. Brandse is very personable and attentive. She makes you feel at ease and takes an interest in you as both a person and patient. She explains her findings and what needs to be done to I,prove results
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02/13/2022 Paul Chapple
Dr. Brandse and her staff have provided exceptional, proactive care and they make MDVIP an obvious choice, well worth the premium. I have recommended Dr. Brandse and MDVIP to many friends and colleagues.
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02/13/2022 Patty Epperly
Expert medical knowledge, good listener, kind, follows through and a staff that answers the phone and communicates diligently are some of the ways that being a patient of Dr. Brandse is an optimal experience.
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02/11/2022 Mary Cerreto
Dr. Brandse is just brilliant and brings to her practice every one of the ideals of MDVIP. She is absolutely thorough in assessing each of my severe health conditions, makes recommendations, and follows through on those recommendations. I’d easily recommend her to anyone looking for a physician in this area.
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11/15/2021 Kimberly Karolides
We love everyone in this office. Dr. Brandse has helped my husband & I on countless occasions. We can always call her when we need to, she returns calls at all hours of the day & night. She is one of the smartest women I know - and she explains everything!
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02/18/2020 Shelly
Dr. Brandse is the best of the best. Her knowledge of all things related to providing excellent medical care is vast and yet she will take the time to ask questions and explain things so that I understand. She also has a great team that is responsive to my phone calls and portal inquiries. All I can say is that I hope I never have to change my doctor. If my employer ever considers changing our insurance plan to one that doesn't include Dr. Brandse, I'd probably have to find a new job. She's THAT good!
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02/16/2020 Jan Tiger
I have been seeing Dr. Brandse for well over 10 years. She is the best doctor I have ever had. She is not only a top notch doctor, but she is also a wonderful person. My entire family now sees her as well. I cannot say enough good things about Dr. Brandse. She is a gem, and I would never want to see another doctor for my primary health care ever again!
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03/17/2019 Laura Schmidt
I have a rare chronic condition that is hardly known to doctors in field. Dr. Brandse has taken the time to learn and help with my condition. I have been with Dr. Brandse for a little over 4 years and have been healthier these last years than I have since I've been sick. I have traveled the country for the best care for this condition and Dr. Brandse seems to know more than specialized drs. Her staff is incredible and her manner is so welcoming, it's not just what I want to see, Dr. Brandse really cares about her patients. Best doctor ever!
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02/17/2019 Patricia Stone
Dr Brandse is the most caring doctor I've ever been to. She also was my mother-in-laws doctor and took the best care of her. She really cares about her patients.
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02/15/2019 Justine Fishman
I have been with Dr. Brandse for a very long time. I have never been disappointed with her care, or the interaction with her support staff. I am confident in the care I receive in this practice.
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03/14/2018 Rita Hettinger
I would like to thank Dr. Brandse for her thoughtfulness and compassion as a doctor. She makes you feel like you are the most important patient she has. She is available days, nights, weekends. Can't ask for anything better than that. You are a wonderful caring doctor and a delightful person to know. I would also like to thank her staff. They work as a "family" and are always attentive when called.

Frequently Asked Questions

Doctors who operate in the MDVIP models typically see far fewer patients than traditional primary care doctors. That gives them more time to develop deeper doctor-patient relationships that can lead to better outcomes. They can also offer conveniences that most primary care doctors can’t, including same- and next-day appointments. They’re available after hours for urgent matters. And they have time to focus on prevention. That focus begins with the MDVIP Wellness Program, which patients pay for with their annual membership fee.

Most MDVIP-affiliated primary care practices accept insurance (your physician can tell you whether they accept your specific insurance plan). Your annual fee pays for preventive care medical services that insurance usually doesn’t cover (e.g., advanced diagnostic testing and screenings). Your MDVIP-affiliated physician will continue to bill your insurance and charge copays, co-insurances and deductibles as he or she currently does for other medical services like sick visits.

MDVIP makes wellness and prevention easier by providing your physician with innovative tools and technology. MDVIP supports your physician’s practice and seeks to eliminate barriers to a positive healthcare experience. Your doctor will determine whether and how to incorporate these tools at his/her discretion.

**The message above is a personal introduction from the physician, intended to help you get to know them better. The views, opinions, and statements expressed above are solely those of the physician and do not necessarily reflect the views or positions of MDVIP. This content is intended for general background purposes only and does not constitute medical advice, diagnosis, or treatment. Any mentions of expertise or quality of care are personal expressions and should not be interpreted as guarantees of performance or outcomes.