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Mark A. Scheperle, MD

Internal Medicine

Hospital Affiliations
St. Luke's Hospital, Barnes Jewish Hospital, St. Mary's Health Center
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Dr. Scheperle

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This physician wants to get to know you and your health needs before you join their practice. Fill out the form to receive more information, or schedule a meeting with Dr. Scheperle.
MDVIP Annual Membership Fee
MDVIP’s annual fee covers the Wellness Program and generally can be made in quarterly, semi-annual and annual payments. Payment options vary by physician.
Quarterly
$550.00*
Semi-Annual
$1,100.00*
Annual
$2,200.00*
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About Mark A. Scheperle, MD

My goal is to manage and anticipate our patients’ unique healthcare needs and evolution. As an MDVIP-affiliated doctor, I will partner with my patients on a personal level to succeed in achieving their optimal health. I will closely collaborate and monitor my patients to help them stay on their pathway to wellness. My service to patients will be individualized, compassionate and timely, all the while encouraging their success in reaching their ultimate health goals.  

Residency

St. Mary's Health Center, St. Louis University
St. Louis, MO
Internal Medicine 1990-1992

Internship

St. Mary's Health Center, St. Louis University
St. Louis, MO
1989-1990

Medical School

University of Missouri-Kansas City School of Medicine
Kansas City, MO
Doctorate of Medicine 1989

St. Luke's Hospital
Barnes Jewish Hospital
St. Mary's Health Center

Associate Professor of Clinical Medicine, Washington University School of Medicine 1992-present
Medical Director, University of Central Missouri 2000-present

American College of Physicians
American College General Practitioners-Diplomate
American Medical Association
American Academy of HIV Medicine
Missouri State Medical Association
St. Louis Metro Medical Association
St. Louis Ambassadors

Missouri

Benefits of joining Dr. Scheperle's practice with MDVIP

MDVIP Wellness Program
Expect comprehensive screenings and tests and a custom wellness plan designed for you.
Better Doctor-Patient Relationship
97% of MDVIP members are satisfied with their relationship (vs 58% in traditional PCP).
Same/Next-Day Appointments
See Dr. Scheperle quickly and take your time during each appointment.
Reachable 24/7
Reach Dr. Scheperle by phone after-hours and on weekends.
Smaller Practice Size
MDVIP practices are smaller than most primary care practices, which means your doctor has more time to help you.
Your Dedicated Doctor
See Dr. Scheperle when you go to the office — not someone else like a nurse practitioner or physician assistant
Travel Benefits
If you need urgent care while traveling, your physician can help arrange your care with a local hospital, pharmacy or doctor.
Medical Centers of Excellence
For patients who need care beyond what is available locally, MDVIP can connect your doctor with specialists at some of the country’s leading medical institutions
Better Health Outcomes
Members have better control of chronic conditions like type 2 diabetes, high cholesterol and hypertension.
Remote video URL

The office of Mark A. Scheperle, MD

Primary Office
1520 South Brentwood Blvd.
Saint Louis, MO 63144
Get Directions
Hours
Mon 7:00 AM - 4:00 PM
Tue 7:00 AM - 4:00 PM
Wed 7:00 AM - 4:00 PM
Thu 7:00 AM - 4:00 PM
Fri 7:00 AM - 4:00 PM
Sat Closed
Sun Closed

What our members are saying

Today, Dr. M Scheperle my (Internal Medicine) doctor, sent out a weekly email about exercise. I would love to write a testimonial about what I learned about exercise. I suffer from several chronic autoimmune illnesses, and yes they are painful. Currently, I am having some different medical issues making it very difficult for me to even exercise at all; however, prior to this experience I…
November 12, 2024
Just having the reassuring knowledge that I have Dr. Mark Sheperle as my doctor is healing. I try hard not to ever abuse that sacred blessing but there are times I've needed him and he is always a text message away. There are so many of these moments - where he has responded to my medical needs - I could write stories that would fill a universe of space. For example, once, after hours, I was in…
March 15, 2024
When I first met Dr Scheperle, I remember him greeting me with a smile. From then on, I knew I would be in the presence of a compassionate human being, who goes the extra mile for his patients, associates and friends. I have known Dr Scheperle for more than 20 years. He has been my personal physician. As our physician, Dr Scheperle played an important role in extending the life of my husband for…
March 3, 2024
Dr. Scheperle, thanks so much for about three decades of being a kind and caring doctor. And thank you for listening. I’m so glad you became an MDVIP doctor. It has definitely made you less stressed and a happier doctor by doing what you do best, being an Internal Medicine Doctor while wanting to help others before illness, and also educating patients about illness. I have learned a lot from your…
February 22, 2024

Reviews from the web

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03/31/2026 Karen Bennette
Dr. Scheperle is the best. Not only does he take the time necessary with, he is very caring. And above all, he is extremely knowledgeable and up-to-date with all medical and pharmaceutical developments. Also very forward thinking. I really can't say enough positive things.
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03/13/2026 Bob Cuneo
Truly the best. Caring. Smart. Timely. Could not ask for better.
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03/13/2026 James Johnson
University Club Medical in Brentwood is an MDVIP-affiliated practice, and that structure truly elevates the entire patient experience. The MDVIP model focuses on personalized preventive care, smaller patient panels, and easier access to your physician — which translates into same-day or next-day appointments, longer unhurried visits, and reliable after-hours availability when something urgent comes up.

Dr. Mark Scheperle and his outstanding nurse practitioner Paula bring that model to life in the best possible way. The level of care here is exceptional. Appointments are incredibly easy to schedule — often the very next morning if something comes up — and when you’re there, you never feel rushed. They take the time to listen, explain things clearly, and practice medicine thoughtfully and precisely.

What really stands out is how warm and welcoming the entire practice feels. Dr. Scheperle has been serving the St. Louis community for decades and founded University Club Medical to provide a highly attentive, patient-centered approach to care. Between him and Paula, you feel like you have a team that genuinely knows you and is invested in your health.

In a healthcare system where many offices feel rushed and impersonal, this practice is the opposite. The accessibility, the attention to detail, and the overall warmth of the team make it something truly rare. I’m incredibly grateful to have Dr. Scheperle, Paula, and the entire University Club Medical team looking after my health.

Highly recommend.
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03/02/2026 Mary Shemesh
Dr Mark Scheperle is a Doctor who truly cares about his patients. He LISTENS to what I’m saying instead my words “ falling on deaf ears “ ! NEVER once have I felt like he was in a rush to get out of the exam room. He’s just A Wonderful and very Intelligent Doctor and I am fortunate to have found him !!!
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02/13/2026 Lee Borrine
Dr. Scheperle is very knowledgeable and communicates well about my healthcare needs. His bedside manner is excellent. He is genuinely concerned about my health and well-being!
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02/13/2026 William Jenkins
Dr Scheperle provides personalized care, pays attention to my specific conditions, and adjusts care until a satisfactory outcome is achieved.
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05/08/2025 Walt M.
Outstanding, welcoming, knowledgeable andb support team and best around the area
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03/16/2025 Joe Hamr
I've been seeing Dr. Mark Scheperle for about 25 years now. I consider him to be the best doctor that I've ever had in my 66 years!!! He's a very knowledgeable, dedicated and compassionate doctor that's primary focus is the health, and well being of all of his patients!! He's also a very friendly, personable man that I consider a very good friend!!!
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03/13/2025 Michael Mcclary
We've been with Mark for over 20 years and couldn't be happier. He's knowledgeable, friendly, and stays on the cutting edge of medicine. Plus he genuinely cares for his patients.
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01/27/2025 Todd Goodrich
Love him and his staff FNP Jennifer Berry who I’ve been seeing her for a couple of years. She is absolutely GREAT! Highly recommend! 5 Gold Stars for Jennifer!!!
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01/24/2025 Star j
he helped me cure my bone infection by giving me at antibiotic shots. I will be forever thankful.
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11/27/2024 Me'Shel Riedel
He is great
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09/16/2024 Marsha Meier
I wouldn’t trust my health with anyone else. Everyone who works at the office is so kind and considerate. Dr. Scheperle has even met me at the office on a Sunday! They are the best.
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03/14/2024 Carol Hartzel
Dr Scheperle and his staff are always willing to listen and help. We have been patients of his for over 20 years and hope to continue our relationship with him for years to come.
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03/12/2024 Jim Washek
Dr Scheperle is the best doctor I have ever encountered. He not only has an exceptional personality, he is fully engaged with his patients.
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02/23/2024 Michael Hickey
I cannot begin to express how impressed I am with the care that I receive under the direction of Dr. Scheperle and his staff. As one who lives with chronic back pain and many other chronic conditions, finding the right healthcare provider is of paramount importance to me. Dr. Scheperle's experience, expertise and compassion are second to none and I am very grateful that I found him.

From the first time I met Dr. Scheperle in his office I felt a sense of calm and was immediately put at ease. He truly cares for his patients and not only listens to all of my concerns, but explains his treatment plan, the rationale for it, and what I can expect as a patient.

Dr. Scheperle's level of empathy, professionalism, honesty and compassion make him one of the most patient-focused caregivers I have ever encountered. I would give Dr. Scheperle and his staff 10 stars if I could.

Thank you dr. Scheperle and staff.
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02/21/2024 Jack Heffner
Gives the gift of empowerment with every visit. i have gotten reintroduced to my body because of this practice and love looking to the future of my health!
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02/11/2024 Chris Sanders
I have been a patient of Dr. Scheperle's for over 20 years. He is one of the most knowledgeable physicians I have ever met, and his listening skills are truly second to none. The rest of his staff is also first rate, especially the two Nurse Practitioners I have seen, Paula and Meghan. Dr. Scheperle and his staff get my very highest recommendation.
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01/25/2024 Megon savalick
Club Medical it's where I go to get my hormonal replacement therapy for my transitioning to another gender everybody's very professional and extremely kind.
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01/18/2024 Melissa Larson Behrend
I recently tried to book a wellness appointment with Dr. Scheperle as he was identified by my Insurance co. as PCP. I was informed by his office in order to be registered as a patient of the Dr. I needed to be a member of MDVIP which has an annual fee of approximately $2000. They did however inform me that they would be happy to book an appointment with one of the 2 nurse practitioners that are on staff at Dr. Scheperle office. I have chosen to go to another PCP provider.
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03/16/2023 PlateletBot
It does not get any better that Dr.Scheperle . In saying that I can see that smile and gleem in his eyes, very knowledgeable . Makes me feel safe even as we age .
Thank you Dr Scheperle !
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03/07/2023 Greta Brown
This is a place with great professionals who take the time to listen and treat you with a respect
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02/22/2023 Matthew Slovinski
Dr Scheperie care has changed my life. I'm a 51 year old disabled Ventren, so I have many health issues. The VA Hospital in St. Louis was just could not keep up with my changes health issues. The damage to my lower spine had gotten so bad that I spent more than a year and half bedridden. Dr Scheperie was able to get my to neurosurgeon that was able to repair my lower spine so now I can walk and have a life agin. The way Dr Scheperie runs his office affords him to have the time not only with you the patient, but also to resurch and locate Specialist to aid Dr Scheperie in your treatment , recovery , and your overall health so you can have QUILITY OF LIFE. I have found with my time with Dr Scheperie that he treats me like a person, NOT A NUMBER. I can not recommend Dr Scheperie enough to you. His care is life changing .
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02/10/2023 Mary Marlow
Dr. Scheperle is the best of both worlds. Extremely smart and extremely kind. I can't thank him enough for the great care he has given my whole family. His staff is terrific too!
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01/24/2023 Sharhonda Jackson
The staff is AMAZING! Dr Scheperle is miles above other MDs. The NPs there are absolute extensions of his care in practicing. There is nothing negative I can say.
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11/27/2022 J D13
I have seen Dr. Scheperle and his nurse practitioners for about fifteen years. They are all incredible. They listen to your concerns, discuss your available options in detail (including holistic options), and always exhibit true concern and interest in improving your health in a professional and very personal manner. I have been a member of his MDVIP program for the last few years and love the personal and prompt care. I consistently recommend Dr. Scheperle to my family and friends for both his general practice and the MDVIP program. His nurse practitioner, Jen is amazing and has provided great care for many years.

My spouse joined this year and required hospitalization and emergency surgery shortly after joining. Dr. Scheperle was amazing with organizing and directing the care my spouse received at the hospital and keeping us informed. This experience was vastly different from my spouse's experience pre-MDVIP and with previous physicians. Dr. Scheperle truly provided VIP and individualized care.
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11/15/2022 Tracy Slovinski
They are an amazing office and caring.
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11/03/2022 Carol Kruger
He’s very courteous and helpful. He listened to what I was saying. He’s very caring and professional.
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08/30/2022 Joe LeBoube
Dr Scheperle and the staff at the office are the best I've ever encountered. I have enjoyed Dr Scheperle so much that I've remained a patient through moves to two different States. Choosing a primary care physician is a very important decision...I am confident you will find what you're looking for with Dr Scheperle.
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08/02/2022 murrel Hopen
Always made to feel welcome.
Always there when we need you. Feel we get the best care available.
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07/28/2022 Rich
I have felt the decline of customer care for about a year now. My original appointment was rescheduled by the office due to there were some building repairs being made. Upon my rescheduled appointment I find out my medical insurance is unexpectedly no longer active. I have been coming to this office I believe since 2014 upon finding out about my insurance I called and asked for the physician assistant whom I see on a regular basis to give me a call, trying to get that request processed was almost impossible because I didn't want to share why I needed my primary care person to call me with the young woman on the phone. I was told that having Megan call me back is going to be almost impossible and she's not going to call if she doesn't know what I want. I did speak to Amanda and though Amanda was much nicer virtually I was told the same thing so I gave a quick synopsis however there were different reasons why I needed to speak to my healthcare provider which I find to be personal.
I did receive a call back from one of the office staff who read a note that my healthcare provider typed. When I inquired as to if my health care provider was going to return my call I was informed that "well she typed this note"
So this just leaves me to believe that because I was informing them of my health insurance situation I wasn't worthy of an actual phone call. I realize everyone is busy and schedules are tight however, when you're in the medical field it's not fair to leave one of your patients hanging with no support. It is not as if I am calling them on a daily basis asking for a phone call. I would like to think if I were a healthcare provider and a patient who rarely calls to speak with me asked for a retun phone call maybe I should give them a phone call.
So, every question I have concerning my health and well-being is still unanswered because of a lack of health insurance during this small window of time and the inability for a phone call to be made.
This is not acceptable where I am concerned. Is this really where we've come? I'm saddened and disappointed at how I have been made to feel by the office of my healthcare provider.
And I'm sure the automatic generic response that will come from this message will be deemed to suffice.
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07/06/2022 ricky phelps
I like coming in and seeing Dr.Scheperle he is always open to listing
to me and my concerns i have with my health care .am so happy that the dr. listen to me if i have concerns with any issues i have thank you Dr. Scheperle
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07/06/2022 William Sprung
You all have been very responsive to ally needs
Thank you
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06/08/2022 LAURA GIOVINO
I see Dr. G.Omondi & he is awesome! Friendly, easier to talk to and very thorough. Staff is also friendly and efficient. I would definitely recommend this practice.
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03/01/2022 Mark Drake
I always get to see Scheperle when I make an appointments. He takes his time and with me and gives me great advice about my health.
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03/01/2022 Noah Behme
I trust this man and his team with my life. I’ve been to endocrinologists all over the country, and he is by far THE BEST.
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03/01/2022 Lisa Jackson-Harren
Healthcare the way it use to be. Dr.S spends time with you and your not just a # to him. The office staff are kind and helpful and the office is beautiful.
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02/17/2022 For Common sense
Dr. Scheperle really cares about his patients. He is a very good doctor. I recommend him to my family and friends.
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02/09/2022 The average Gamer
Dr. Scheperle is the best doctor I’ve ever had. I trust him completely and always know I can count on him. He’s always on top of the most recent research. Besides seeing him for office visits, I have on occasion been able to contact him on weekends and on holidays when I’ve had emergencies—thanks to MDVIP! When I had to go to the ER, he called ahead of time and they were expecting me by the time I got there. When I’ve needed to see specialists, he’s always recommended the best ones in area. In addition, he’s closely communicates with those specialists and with me. Clearly, I can’t say enough about how awesome Dr. Scheperle is!!!
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01/20/2022 Robert Otto
I started seeing Dr. Scheperle over 20 years ago for migraines. He was the only one to actually diagnose me and help me find my triggers. He is a wonderful Dr. and friend. I have recommended to sever other friends and family members. They love him as well.
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12/16/2021 Norm Hoback
My wife and I have been patients for around 20 years. We stayed with him when he went with MDVIP, and we are very glad we did. Every time we've needed help Dr. Scheperle was there with us from beginning to end. He and his staff are willing to do what it takes to get care for their patients. When one of us was in hospital this year, he was available any time there was a question, often calling me for an update if I hadn't sent one lately. Couldn't ask for more!
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12/16/2021 Joan C. Lauterwasser
Bob and I thank God for having you as our doctor and now friend. Thank you for all you do.

Frequently Asked Questions

Doctors who operate in the MDVIP models typically see far fewer patients than traditional primary care doctors. That gives them more time to develop deeper doctor-patient relationships that can lead to better outcomes. They can also offer conveniences that most primary care doctors can’t, including same- and next-day appointments. They’re available after hours for urgent matters. And they have time to focus on prevention. That focus begins with the MDVIP Wellness Program, which patients pay for with their annual membership fee.

Most MDVIP-affiliated primary care practices accept insurance (your physician can tell you whether they accept your specific insurance plan). Your annual fee pays for preventive care medical services that insurance usually doesn’t cover (e.g., advanced diagnostic testing and screenings). Your MDVIP-affiliated physician will continue to bill your insurance and charge copays, co-insurances and deductibles as he or she currently does for other medical services like sick visits.

MDVIP makes wellness and prevention easier by providing your physician with innovative tools and technology. MDVIP supports your physician’s practice and seeks to eliminate barriers to a positive healthcare experience. Your doctor will determine whether and how to incorporate these tools at his/her discretion.

**The message above is a personal introduction from the physician, intended to help you get to know them better. The views, opinions, and statements expressed above are solely those of the physician and do not necessarily reflect the views or positions of MDVIP. This content is intended for general background purposes only and does not constitute medical advice, diagnosis, or treatment. Any mentions of expertise or quality of care are personal expressions and should not be interpreted as guarantees of performance or outcomes.